AstraZeneca/trim21-bioprotac

Bioinformatics data analyses - Fletcher A. et al., Nature Communications 2023, doi: 10.1038/s41467-023-42546-2

Bioinformatics data analysis code accompanying:

Fletcher, A., Clift, D., de Vries, E. et al. A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation. Nat Commun 14, 7093 (2023). https://doi.org/10.1038/s41467-023-42546-2

Software requirements:

• R 3.6.0 with libraries: devtools 2.3.2, tidyverse 1.3.0, yaml 2.2.1, data.table 1.13.2, limma 3.42.2, ggplot2 3.3.2, ggrepel 0.9.1, VennDiagram 1.6.20
• Python 3.6.6

To reproduce the data analyses, the figures and tables in the paper, install the software requirements and run the scripts

Release at time of publication: Any updates will be managed directly using this GitHub page