/EED-HDAC

Bioinformatics analysis in EED-HDAC project, "Polycomb EED Orchestration of Heart Maturation is PRC2-independent".

Primary LanguageRGNU General Public License v3.0GPL-3.0

EED-HDAC

EED regulates gene expression independently of H3K27me3 through controlling H3K27ac level.

Bioinformatics analysis in EED-HDAC project, "Transcriptional repression by non-canonical EED stimulation of histone deacetylase activity is required for heart maturation independently of H3K27me3".

Reference:

Shanshan Ai^, Yong Peng^, Chen Li, Fei Gu, Xianhong Yu, Yanzhu Yue, Qing Ma, Jinghai Chen, Zhiqiang Lin, Pingzhu Zhou, Huafeng Xie, Terence W Prendiville, Wen Zheng,Yuli Liu, Stuart H Orkin, Da-Zhi Wang, Jia Yu,William T Pu*, Aibin He*. (2017). EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. eLife, 6:e24570. PMID:28394251