/Spindle-Modeling-budding-yeast

In this project the motility dynamics of spindle pole body, nucleus and spindle is modeled during the cell cycle

Modeling-budding-yeast

In this project the motility dynamics of spindle pole body, nucleus and spindle is modeled during the cell cycle

  1. Geomtery of cell: file in the path: ./input/CellCoors.out
    ( and some other example files included )

  2. Geometry of spindle: elliposidal and dumbell ( two rep. examples included to illustrate )

  3. Models for dynein localization as

     a. uniform arc: "yeast_bud_mdX.cym"

 b. offloading of dynein on mother and bud cortex: symmetric and/or differential
 		
 c. offloading only at the bud-cortex

  4. MT asymmetry model a. Differential MT dynamics of MTs emanating from the mother and daughter SPBs

  5. CYTOSIM PI version ed5c1f1

  6. Also, PoC: SPB-nucleus dynamics simulated in a cell-free system

Some parts of the work published in Jain, K, Khetan, N, Yadav, SA, Palani, S, Athale, CA. Collective dynein transport of the nucleus by pulling on astral microtubules during Saccharomyces cerevisiae mitosis. Yeast. 2021; 38: 352– 366. https://doi.org/10.1002/yea.3552