Infiltrating Macrophage in Metastatic Urothelial Cancer determines immunophenotype and predicts anti-PD-L1 response
Comprehensive analysis highlighted and verified the robust predictive value of Macrophage M1 and its essential role in immunophenotype determination among patients with mUC. With multi-omics research of 348 pre-treatment mUC patients and eternal validation, we demonstrated that macrophage M1 infiltration was a promising biomarker for prognosis and immunotherapeutic response prediction, non-inferior to tumor mutation burden (TMB) and tumor neoantigen burden (TNB) and exceeding other reported predictors (CD8+ T cell, GEP, PD-L1).
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Step-1: Tumor microenvironment deconvolution. We developed an R package IOBR to estimate fraction of multiple cell types and signature score of tumor.
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Step-2: Estimation of feature importance. We developed an R package Blasso to integrating LASSO cox regression and bootstrapping algorithm to find best prognostic features
Zeng D, Ye Z, Wu J, Zhou R, Fan X, Wang G, Huang Y, Wu J, Sun H, Wang M, Bin J, Liao Y, Li N, Shi M, Liao W. Macrophage correlates with immunophenotype and predicts anti-PD-L1 response of urothelial cancer. Theranostics 2020; 10(15):7002-7014. doi:10.7150/thno.46176
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