MR.CUE is a package for Mendelian randomization informs shared genetic etiology underlying exposure and outcome by interrogating correlated horizontal pleiotropy.
Install the development version of MR.CUE by use of the 'devtools' package. Note that MR.CUE depends on the 'Rcpp' and 'RcppArmadillo' package, which also requires appropriate setting of Rtools and Xcode for Windows and Mac OS/X, respectively.
library(devtools)
install_github("QingCheng0218/MR.CUE@main")
If you have errors installing this package on Linux, try the following commands in R:
Sys.setlocale(category = "LC_ALL", locale = "English_United States.1252")
Sys.setenv(LANG="en_US.UTF-8")
Sys.setenv(LC_ALL="en_US.UTF-8")
library(devtools)
install_github("QingCheng0218/MR.CUE@main")
The 'MR.CUE' vignette will provide a good start point for Mendelian randomization analysis using MR.CUE package.
Qing Cheng, Xiao Zhang, Lin S. Chen+, Jin Liu+. Mendelian randomization accounting for complex correlated horizontal pleiotropy while elucidating shared genetic etiology. Nat Commun 13, 6490 (2022). https://doi.org/10.1038/s41467-022-34164-1
This package is developed and maintained by Qing Cheng (qingcheng0218@gmail.com).
Cite the code:
