/Overlap

Correcting the overlapping bias in Mendelian Randomization with summary statistics

Primary LanguageR

Correcting the bias of overlap with the weak instrument in Mendelian Randomization

The IVW_exact_olap is a function for correcting the bias of overlap between the study of genetic variant-exposure association and genetic-variant-outcome association. We extend the method in Bowden et al, 2018 to account for the correlation due to the overlap in the two studies. The source of this function is from GitHub of Wes Spiller. We just add the correlation part to take into account sample overlapping.

Reference:

  • Jack Bowden and others, Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption, International Journal of Epidemiology, 48(3), June 2019, Pages 728–742, https://doi.org/10.1093/ije/dyy258