The CancerInSilico package provides an R interface for running mathematical models of tumor progresson. This package has the underlying models implemented in C++ and the output and analysis features implemented in R.
CancerInSilico is a bioconductor R package (link) and so the release version can be installed as follows:
install.packages("BiocManager")
BiocManager::install("CancerInSilico")
The most up-to-date version of CancerInSilico can be installed directly from the FertigLab Github Repository:
BiocManager::install("FertigLab/CancerInSilico")
Follow the vignette here