/clonal-lohhla

Subclonal determination of HLA LOH

Primary LanguagePython

Clonal HLA LOH inference

Basic workflow probabilistic inference of clonal HLA LOH.

Refer to example input files under data/.

Requirements:

  • Tree edges: Two-column table specifying the clonal phylogeny (0 = root)
  • Clonal prevalences: Table of clonal prevalences
  • Ploidy and cellularity (similar input format to LOHHLA)
  • Read stats: Unique read counts from flagstat
  • HLA loss table: Output of LOHHLA, but tab-separated
  • CPN table: Output of LOHHLA, but tab-separated

Dependencies

  • python2.7
  • numpy
  • pandas
  • pymc3
  • theano
  • matplotlib

TODOs

  • Add versions
  • Properly document