/thermophilesNAD

Contains NAD biosynthesis model and python scripts to simulate the steady-state calculations.

Primary LanguageJupyter NotebookGNU General Public License v3.0GPL-3.0

thermophilesNAD

A coarse-grained temperature dependent model of NAD metabolism via PNCA and NAMPT.

The computational framework is developed using Python3.

1. Getting python

You can download the latest version of Python here. Alternatively, you can use Anaconda to install python for your computer (Linux, Windows, Mac).

2. Cloning the repository

via SSH:

  git clone git@github.com:MolecularBioinformatics/thermophilesNAD.git

via HTTPS:

  git clone https://github.com/MolecularBioinformatics/thermophilesNAD.git

via GitHub CLI:

  gh repo clone MolecularBioinformatics/thermophilesNAD

2. Installing packages using requirement file

  cd thermophiles
  pip install -r requirements.txt

Once you have checked the steps above, start a python console to simulate thesteady-state metabolic concentrations of NAD biosynthesis.

3. To reproduce plots from the manuscript type the following in your python console:

run plotresults.ipynb