Whole-body PBPK model of carbamazepine
This repository contains:
- a PK-Sim snapshot (*.json) file of the current PBPK model
- static content (e.g. text blocks, *.md files) as inputs for an evaluation plan
- an evaluation plan (evaluation-plan.json) to create an evaluation report using the snapshot and static text blocks to display the performance of the model
The latest release of the snapshot of the model, the evaluation plan and the static content can be found here.
The latest release of the PK-Sim project model file and the respective evaluation report can be found here.
The carbamazepine model provided herein differs from the model originally published by Fuhr et al. [1] with respect to the model structure and parameterization. The metabolite carbamazepine-10,11-epoxide is not explicitly modeled here.
The model was developed using a large number of clinical studies and is intended to be used as perpetrator drug in CYP3A4-mediated drug-drug interactions (DDI).
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The model code is distributed under the GPLv2 License.