/IFN-alpha

A multiscale QSP model of IFN-alpha induced activation of the JAK/STAT pathway in human liver cells (Kalra et al., 2019)

IFN-alpha

A multiscale QSP model of IFN-alpha induced activation of the JAK/STAT pathway in human liver cells ([1,2]).

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Contribution

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License

The model code is distributed under the GPLv2 License.

References

[1] Kalra P, Brandl J, Gaub T, Niederalt C, Lippert J, Sahle S, et al. (2019) Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach. PLoS ONE 14(2): e0209587. https://doi.org/10.1371/journal.pone.0209587

[2] Maiwald T, Schneider A, Busch H, Sahle S, Gretz N, Weiss TS, et al. (2010) Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon α-induced early antiviral signalling. FEBS J. 2010 Nov;277(22):4741-54. doi: 10.1111/j.1742-4658.2010.07880.x