An SGC Open Chemistry Networks Project (number 4) devoted to a site on the SARS-CoV-2 Non-structural protein 13 (NSP13)
The site of interest is "C-terminus-B" referred to by this paper that reported the original fragment screen. (Not the RNA or nucleotide site).
You contribute synthetic chemistry and in return the SGC offers biology. Together we can generate tool compounds to understand biology and validate drug targets to help cure disease. Everything is open, with all content governed by a CC-BY-4.0 licence.
If this sounds interesting, and you agree to the simple RULES, you can get started.
For the science background, head to the wiki or check out the living paper that is being written here (link is also https://tinyurl.com/SGC-CNP4).
For answers to all the questions you have, go to the FAQs.
If you'd like to contact someone to talk about contributing, then write something in an Issue (see the tab above), which is a good way to communicate openly. (Issues describe what currently needs doing and act as a discussion forum - you need a Github account but it's super easy and not spammy. To tag everyone involved in this project on Github use "@StructuralGenomicsConsortium/cnp4-nsp13". There's also an email address (chemistry@thesgc.org) you can use to ask questions.
Current scientific status of the project is on the wiki (you can always find the relevant tab above). The current version of the research paper describing this project is NEEDED here and is a great place to start if you're new to all this.
Some humans involved in this Open Chemistry Networks Project:
Professor Tim Willson, University of North Carolina Chapel Hill (medchem) @tmw20653
Professor Alex Tropsha, University of North Carolina Chapel Hill (computational chem)
Professor Matthew Todd, University College London. Head of Chemistry Networks at the SGC (medchem) @mattodd
Tom Knight, University College London (medchem) @TomkUCL
Dr Edwin Tse, University College London (medchem) @edwintse
Professor Konstantin Popov, University of North Carolina Chapel Hill (computational chem) @kipUNC
Dr Hebaallah Agha, University of North Carolina Chapel Hill (medchem) @H-agha
Dr Santha Santhakumar, SGC (project management) @Santha-SGC
Dr Masoud Vedadi, SGC Toronto (biology)
Dr Sumera Malik, SGC Toronto (protein science) @SumeraMalik123
Dr Anwar Hossain, University of North Carolina Chapel Hill (medchem) @ahsgc
Pharma Champion: Dr James Day, Astex Pharmaceuticals @jamesday100 (Feb 2022-Dec 2023), currently vacant.
The Sir James Murray Student Champion: Tom Knight (University College London), @TomkUCL.
You can see other contributors in the Issues (tab above).
Online meetings for this project:
Fortnightly half-hour catch-ups looking at details. Not recorded. Alternate Fridays at 1:30pm UK time at https://ucl.zoom.us/j/96175412490
Monthly big picture meetings involving the Pharma Champion. Recorded and put online. Second Monday of each month at 5pm UK time. https://ucl.zoom.us/j/97172937586
The licence for the content of this project is, unless otherwise stated, and as for all OCN projects, CC-BY-4.0. This means you can do whatever you like with the project content, including making money, provided you cite the project.
This project is part of the SGC's Open Chemistry Networks initiative.
