TAR_Thermodynamic_Model

Ensembles, Scripts and 3DNA-DSSR Data to generate figures and analysis used in the manuscript

RNA conformational propensities determine cellular activity

Megan L Kelly1, Rohit Roy2, Ainan Geng1, Laura R Ganser3, Akanksha Manghrani1, Bryan R. Cullen4, Ursula Schulze-Gahmen5, Daniel Herschlag6 and Hashim M. Al-Hashimi1*

1 Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA

2 Center for Genomic and Computational Biology, Duke University School of Medicine, Durham, NC 27710, USA

3 Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA

4 Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA

5 Gladstone Institute of Virology, San Francisco, CA 94158, USA

6 Department of Biochemistry, Stanford University, Stanford, CA 94305, USA

7 Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA

*Corresponding author. Email: ursula.schulzegahmen@gladstone.ucsf.edu (U.S-G.); herschla@stanford.edu (D. H.); ha2639@cumc.columbia.edu (H. M. A)