This is a small collection of Natural Products Papers (mostly for introducing undergrads working with me) https://www.ncbi.nlm.nih.gov/books/NBK26866/
http://pubs.rsc.org/en/journals/articlecollectionlanding?sercode=np&themeid=71377851-6603-4d7c-80eb-7aceb28aed4c https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853187/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850076/
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A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation. Thomas De Vijlder, Dirk Valkenborg, Filip Lemière, Edwin P. Romijn, Kris Laukens, Filip Cuyckens
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Henke MT, Kelleher NL. Modern mass spectrometry for synthetic biology and structure-based discovery of natural products. Natural product reports. 2016;33(8):942-950. doi:10.1039/c6np00024j.
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Covington BC, McLean JA, Bachmann BO. Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites. Natural product reports. 2017;34(1):6-24. doi:10.1039/c6np00048g.
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Mass spectrometry of natural products: current, emerging and future technologies; Amina Bouslimani, Laura M. Sanchez, Neha Garg, and Pieter C. Dorrestein
- http://pubs.rsc.org/en/content/articlelanding/2014/np/c4np00044g#!divAbstract
- Occurs in a special issue, other articles in the issue are here: http://pubs.rsc.org/en/journals/articlecollectionlanding?themeid=4d49-6d56-14a6-2b79-c1d6-d55f-221c-93b2
- Cimermancic P, Medema MH, Claesen J, et al. Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell. 2014;158(2):412-421. doi:10.1016/j.cell.2014.06.034.
- Cruz-Morales P, Kopp JF, Martínez-Guerrero C, et al. Phylogenomic Analysis of Natural Products Biosynthetic Gene Clusters Allows Discovery of Arseno-Organic Metabolites in Model Streptomycetes. Genome Biology and Evolution. 2016;8(6):1906-1916. doi:10.1093/gbe/evw125.
- Omics-based natural product discovery and the lexicon of genome mining
Henrique Machado1, Robert N Tuttle, and Paul R Jense; Current Opinion in Microbiology, Volume 39, 2017
- https://www.sciencedirect.com/science/article/pii/S136952741730108X?via%3Dihub
- Also includes recommended reading
- https://www.sciencedirect.com/science/article/pii/S136952741730108X?via%3Dihub
- Cracking the regulatory code of biosynthetic gene clusters as a strategy for natural product discovery Sébastien Rigali, Sinaeda Anderssen, Aymeric Naômé, Gilles P. van Wezel; Biochemical Pharmacology, 2018 - https://www.sciencedirect.com/science/article/pii/S0006295218300078#s0010
- Recent development of computational resources for new antibiotics discovery Hyun Uk Kim, Kai Blin, Sang Yup Lee, Tilmann Weber; Current Opinion in Microbiology, Volume 39, 2017
- Coupling MALDI-TOF mass spectrometry protein and specialized metabolite analyses to rapidly discriminate bacterial function. Clark, C. M.; Costa, M. S.; Sanchez, L. M.; Murphy, B. T. 2018. Manuscript under review. Biorxiv Preprint
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Where to start:
- swirlstatscom
- r4ds.had.co.nz
- Then move on to: adv-r.had.co.nz
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Where to find answers to your questions:
- stackexchange.com
- community.rstudio.com
- Web Search! (i.e. google.com)
- E.g. (search: convert list to data frame in R)
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Shiny resources:
- In R
- In Python
- Section "6.4.3 Remarks on Statistical Problems with MS Data"
https://developers.google.com/machine-learning/crash-course
- Discrimination ability: