/npPapers

Collection of Natural Products Papers (mostly for intro)

npPapers

This is a small collection of Natural Products Papers (mostly for introducing undergrads working with me) https://www.ncbi.nlm.nih.gov/books/NBK26866/

http://pubs.rsc.org/en/journals/articlecollectionlanding?sercode=np&themeid=71377851-6603-4d7c-80eb-7aceb28aed4c https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853187/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850076/

Mass Spectrometry

Distribution of NPs across the tree of life

  • Cimermancic P, Medema MH, Claesen J, et al. Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell. 2014;158(2):412-421. doi:10.1016/j.cell.2014.06.034.
  • Cruz-Morales P, Kopp JF, Martínez-Guerrero C, et al. Phylogenomic Analysis of Natural Products Biosynthetic Gene Clusters Allows Discovery of Arseno-Organic Metabolites in Model Streptomycetes. Genome Biology and Evolution. 2016;8(6):1906-1916. doi:10.1093/gbe/evw125.

Genome Mining

IDBac

  • Coupling MALDI-TOF mass spectrometry protein and specialized metabolite analyses to rapidly discriminate bacterial function. Clark, C. M.; Costa, M. S.; Sanchez, L. M.; Murphy, B. T. 2018. Manuscript under review. Biorxiv Preprint

R

Resources

Data Analysis

GNPS

Network Analysis

Hierarchical Clustering (MALDI)

PCA

t-SNE

Statistics & MALDI

Machine Learning

https://developers.google.com/machine-learning/crash-course

16S