Determine depency of delG error on dPstated
sonyahanson opened this issue · 1 comments
Tested the effect of changing dPstated = 0.35 * inputs['Pstated']
to dPstated = 0.15 * inputs['Pstated']
. Interestingly, this removed the long tails for the Src-Erlotonib fits, changing them from this (dPstated = 0.35 * inputs['Pstated']
):
to this (dPstated = 0.15 * inputs['Pstated']
):
Similarly for the same number of iterations, running the same job three times gives more consistent answers with dPstated at 0.15, changing this (dPstated = 0.35 * inputs['Pstated']
):
This is very interesting!
dPstate =0.15
can still be a realistic number. I wonder what would happen if you make uncertainty in protein concentration absurdly low. Something like dPstate =0.01 or 0.001
. I wonder if fitting the model will get more difficult or will DeltaG uncertainties get narrower and narrower making the model look better (perhaps wrongly).