/snareseq_tf

Multimodal analysis of transcription factor activity using single-cell transcriptome and chromatin accessibility data

Primary LanguageJupyter Notebook

SNARE-seq Transcription Factor Analysis

jupyter notebook, python 3.7.3

This workflow was made to assess previously unknown TF-gene relations by evaluating the joint single-cell transcriptome and chromatin accessibility data published with the SNARE-seq method

  • sig_peaks.fasta is a list of all open chromatin regions with a significant effect on gene expression (multiple-hypothesis 2-sided t-test)
  • snareseq_tfs.csv is a document of the tf-gene pairs found by using this prototype workflow

Special thanks to Dr. Ziv Bar-Joseph and the CMU Systems Biology Group