A multiomic apprach to characterizing H2S production by the human gut microbiome
This is the code repository for the manuscript "The capacity to produce hydrogen sulfide (H2S) via cysteine degradation is ubiquitous in the human gut microbiome" published by Frontiers in Microbiology: Microbial Physiology and Metabolism.
In this projcet, we searched thousands of bacterial reference genomes for genes capable of hydrogen suflide (H2S) production via cysteine degradation. This required creating a custom, multifacted computational workflow which we have visualized here (Supplementary Figure 1 from the manuscript):
We found that cysteine degrading genes are ubiquitous in the human gut microbiome and may contribute significantly to overall H2S production in the healthy, inflammatory bowel disease (IBD) and colorectal cancer (CRC) gut.
