clearly emphasize that IFN remains stochastic in NS+ and NS- cells

Question

clearly emphasize that IFN remains stochastic in NS+ and NS- cells

Closed this issue 6 years ago · 2 comments

This is stated, but possibly should be stated even more clearly.

Answer 1 · 2018-12-21T01:59:29.000Z

I was thinking we could emphasize this for ALL mutants we test (and can cite prior work from Randall), and then transition to the burden and ribavirin to partially explain remaining IFN induction? Can do a sub-figure in supplement showing all NS- IFN+ and IFN- cells and genotypes. No statistical argument to be made, but at least an evocative one showing no single defining genetic characteristic driving non-deterministic behavior.

Answer 2 · 2018-12-26T18:37:41.000Z

Text in the genotypes section now clearly calls out that there are NS- cells that don't induce IFN.