Algorithms to detect mutational hotspots. Currently, MutationHotspotsDetection only supports detection of intra-chain hotspots in 3D protein structures.
Binary JAR file is available in releases.
java -jar MutationHotspotsDetection-1.2.1.jar <input.maf> <output.results.txt>
Here is an example input MAF file
Either ENSP or SWISSPROT should have data for each mutation. CODE is not required. All other columns are required.
IMPORTANT: The mutations in the input MAF should be pre-sorted by ENSP or SWISSPROT column.
Gao J, Chang MT, Johnsen HC, Gao SP, Sylvester BE, Sumer SO, Zhang H, Solit DB, Taylor BS, Schultz N, Sander C. 3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets. Genome Med. 2017 Jan 23;9(1):4. doi: 10.1186/s13073-016-0393-x.