aliskiren model

This repository provides the aliskiren physiologically based pharmacokinetics (PBPK) model.

The model is distributed as SBML available from aliskiren_body_flat.xml with corresponding SBML4humans model report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_body_flat.xml and equations from aliskiren_body_flat.md.

Comp submodels

The liver submodel is available from aliskiren_liver.xml with corresponding SBML4humans report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_liver.xml and equations from aliskiren_liver.md.

The kidney submodel is available from aliskiren_kidney.xml with corresponding SBML4humans report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_kidney.xml and equations from aliskiren_kidney.md.

The intestine submodel is available from aliskiren_intestine.xml with corresponding SBML4humans report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_intestine.xml and equations from aliskiren_intestine.md.

The whole-body submodel is available from aliskiren_body.xml with corresponding SBML4humans report at https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_body.xml and equations from aliskiren_body.md.

How to cite

Kulanoglu, Y. A., & König, M. (2024). Physiologically based pharmacokinetic (PBPK) model of aliskiren.
Zenodo. https://doi.org/10.5281/zenodo.13758627

License

Source Code: LGPLv3
Documentation: CC BY-SA 4.0
Models: CC BY-SA 4.0

The aliskiren-model source is released under both the GPL and LGPL licenses version 2 or later. You may choose which license you choose to use the software under.

This program is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License or the GNU Lesser General Public License as published by the Free Software Foundation, either version 2 of the License, or (at your option) any later version.

This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.

Funding

Matthias König was supported by the Federal Ministry of Education and Research (BMBF, Germany) within LiSyM by grant number 031L0054 and ATLAS by grant number 031L0304B and by the German Research Foundation (DFG) within the Research Unit Program FOR 5151 QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach) by grant number 436883643 and by grant number 465194077 (Priority Programme SPP 2311, Subproject SimLivA). This work was supported by the BMBF-funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B).