/Bidirectional_PD_Smell

Primary LanguageJupyter Notebook

Bidirectional relationship between olfaction and Parkinson’s disease

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DOI

  • Project: Bidirectional relationship between olfaction and Parkinson’s disease
  • Author(s): Jonggeol Jeffrey K., Sara Bandres C., Karl H., 23andMe Research Team, Cornelis B., Alastair N.
  • Date Last Updated: Aug 2024
    • Update Description: Create README

Description:

Determine the genomic relationship between hyposmia and Parkinson's disease (PD) using shared heritability analyses (genetic correlation) and Mendelian randomization. To this end, we use linkage disequilibrium score regression (LDSC.ipynb), Local Analysis of [co]Variant Association (LAVA.ipynb), and Two-sample Mendelian randomization (MR.ipynb).

Software and packages used:

  • Python v3.7
  • R v4.2
  • LDSC v1.0.1
  • LAVA v0.1.0
  • TwoSampleMR v0.5.7
  • data.table v1.14.0
  • tidyverse v2.0.0
  • vroom v1.0.0
  • LocusCompareR v1.0.0