/mobest

R Package - Spatiotemporal Ancestry Interpolation and Search

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GitHub R package version R-CMD-check

mobest

This R package provides types and functions for spatiotemporal interpolation of human genetic ancestry components, probabilistic similarity search and the calculation of a derived measure for mobility estimation. The workflow in mobest version 1.0.0 was specifically developed to support this research compendium for this paper.

See the documentation at https://nevrome.de/mobest

  • mobest assumes you have a set of genetic samples with spatial (two coordinates in a projected reference system) and temporal positions (years BC/AD) for which you calculated a derived, numeric measure of genetic ancestry (e.g. coordinates in a PCA or MDS space).
  • mobest provides a framework to perform spatiotemporal interpolation using Gaussian process regression (kriging) with the laGP package to reconstruct an ancestry field based on the ancestry measure you provided.
  • mobest finally allows to derive a similarity probability for samples of interest within the interpolated field, which – under certain circumstances – can be interpreted as an origin probability.