/CovadjustSim

Simulation Studies of the effect of covariate adjustment on the statistical power of treatment effect estimation in a clinical tiral

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CovadjustSim

The goal of CovadjustSim is to ensure the reproducibility of the results presented in the paper “More efficient and inclusive time-to-event trials with covariate adjustment: a simulation study”.

Additionally, it may also be useful for power analysis for models based on the proportional hazard assumption.

Installation

You can install the development version of CovadjustSim from GitHub with:

# install.packages("devtools")
devtools::install_github("owkin/CovadjustSim")

Simulation results

All simulation results are summarised in vignettes:

vignettes("power", package = "CovadjustSim")
vignettes("eligibility", package = "CovadjustSim")

Steps to reproduce the results of parametric simulations are available in the source codes under the folder data-raw.

Power analysis with simulations

TBD