Feature request: add option to perform gene burden analysis

Question

Feature request: add option to perform gene burden analysis

Opened this issue 3 months ago · 3 comments

berntpopp commented 3 months ago

This will require subsetting into cohorts and applying a model/ statisical test.

Answer 1 · 2024-06-19T14:13:23.000Z

also see https://github.com/halbritter-lab/stoneformers-multisample-vcf/issues/4

Answer 2 · 2024-06-27T12:15:28.000Z

Relates to #23

Also add counts for cohort sizes (control vs. affected)

Answer 3 · 2024-07-13T19:14:34.000Z

I think this should be for now a simple test like Fishers exact probands vs. controls with FDR correction of the values just on the merged variant counts.