Journal_Club_ZJU

药物设计

2023/10/18

  • An antibiotic from an uncultured bacterium binds to an immutable target.
  • Teixobactin kills bacteria by a two-pronged attack on the cell envelope.

生物大分子

2023/10/18

  • A succinate/SUCNR1-brush cell defense program in the tracheal epithelium.

肿瘤免疫

2023/10/18

  • A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands.
  • An unexplored angle: T cell antigen discoveries reveal a marginal contribution of proteasome splicing to the immunogenic MHC class I antigen pool.

模型方法

  • Efficient sampling of high-dimensional free energy landscapes using adaptive reinforced dynamics.