CIRCLET, a powerful tool for accurate reconstruction of circular trajectory with high resolution by considering multi-scale features of chromosomal architectures of single cells. Further division of the reconstructed trajectory helps to accurately characterize the dynamics of chromosomal structures and uncover important regulatory genes along cell-cycle progression, providing a novel framework for discovering regulatory regions even cancer markers at single-cell resolution.
zhanglabtools/CIRCLET
CIRCLET, a powerful tool for accurate reconstruction of circular trajectory with high resolution by considering multi-scale features of chromosomal architectures of single cells. Further division of the reconstructed trajectory helps to accurately characterize the dynamics of chromosomal structures and uncover important regulatory genes along cell-cycle progression, providing a novel framework for discovering regulatory regions even cancer markers at single-cell resolution.
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