API for managing and serving Multi-Omics Digital Object System (MODOS).
Provide a digital object and system to process, store and serve multi-omics data with their metadata such that:
- Traceability and reproducibility is ensured by rich metadata
- The different omics layers are processed and distributed together
- Common operations such as liftover can be automated easily and ensure that omics layers are kept in sync
The digital object is composed of a folder with:
- Genomic data files (CRAM, FASTA)
- A zarr archive for metadata and array-based database
The metadata links the different files using the modos-schema.
The development version of the library can be installed from github using pip:
pip install git+https://github.com/sdsc-ordes/modos-api.git@mainThe user facing API is in modos.api. It allows to interact with existing digital objects:
from modos.api import MODO
ex = MODO('./example-digital-object')
ex.list_files()
ex.list_samples()The development environment can be set up as follows:
git clone https://github.com/sdsc-ordes/modos-api && cd modos-api
make installThis will install dependencies and create the python virtual environment using poetry and setup pre-commit hooks with pre-commit.
The tests can be run with make test, it will execute pytest with the doctest module.
- To allow faster horizontal traversal of digital objects in the catalogue (e.g. for listing), the metadata should be exported in a central database/knowledge-graph on the server side.
- Metadata can be either embedded in the array file, or stored in a separate file
- Each digital object needs a unique identifier
- The paths of individual files in the digital object must be referenced in a consistent way.
- Absolute paths are a no-go (machine/system dependent)
- Relative paths in the digital object could work, but need to be OS-independent
- Focusing on data retrieval, remote object creation not yet implemented
- The htsget protocol supports streaming CRAM files, but it is currently only implemented for BAM in major genome browsers (igv.js, jbrowse)
The development of the Multi-Omics Digital Object System (MODOS) is being funded by the Personalized Health Data Analysis Hub, a joint initiative of the Personalized Health and Related Technologies (PHRT) and the Swiss Data Science Center (SDSC), for a period of three years from 2023 to 2025. The SDSC leads the development of MODOS, bringing expertise in complex data structures associated with multi-omics and imaging data to advance privacy-centric clinical-grade integration. The PHRT contributes its domain expertise of the Swiss Multi-Omics Center (SMOC) in the generation, analysis, and interpretation of multi-omics data for personalized health and precision medicine applications. We gratefully acknowledge the Health 2030 Genome Center for their substantial contributions to the development of MODOS by providing test data sets, deployment infrastructure, and expertise.
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